Trump Makes Major Drug Price Announcement: ‘End Of Great American Ripoff’
President Donald Trump announced Tuesday that Americans will soon be able to purchase popular medications at steeply discounted “most-favored-nation” prices, as pharmaceutical giant Pfizer committed to a historic $70 billion investment to expand U.S.-based manufacturing.
President Trump: “All new medications introduced by Pfizer to the American market will be sold at the reduced, most favored nation cost.” pic.twitter.com/S2CQxh7PKC
— CSPAN (@cspan) September 30, 2025
A new federal platform, TrumpRX, will allow consumers to buy medications directly from the government rather than through insurance companies. According to the White House, nearly every prescription drug will see substantial discounts through the program.
Pfizer’s $70 billion pledge represents a major shift toward domestic production, which the Trump administration has repeatedly described as a national security priority. The company will also extend most-favored-nation pricing — matching or undercutting the lowest prices charged in other developed nations — to Medicaid and to all new drugs moving forward.
The savings will be dramatic. A common dermatitis drug will see an 80% cut off the net price, post-menopausal osteoporosis medication will be reduced by 85%, and migraine treatments and rheumatoid arthritis drugs will be discounted by 50% and 40%, respectively.
Food and Drug Administration Commissioner Dr. Marty Makary said the initiative will not stall innovation but will instead rebalance the costs so American patients are no longer the only ones underwriting global research and development.
“Today marks the end of the great American ripoff,” Makary said. “For years I’ve watched patients scramble to pay for medicine that costs five or ten times more in the United States than in France, Germany, or the U.K. This reform ends that injustice.”
.@DrMakaryFDA: “Today marks the the beginning of the end of the great American rip off, and it also marks the beginning of the end of a great American tragedy; something I’ve seen as a physician at the bedside — patients getting spun up into a financial rage… to try to get… pic.twitter.com/SD0iKsZR2B
— Rapid Response 47 (@RapidResponse47) September 30, 2025
Dr. Mehmet Oz, administrator of the Centers for Medicare & Medicaid Services, agreed, saying the new policy both secures affordable access to existing medicines and protects medical advances for the future.
.@DrOzCMS: “In July, President Trump demanded that manufacturers make a firm commitment to lower their prices “or else.” Last week, we made a major breakthrough. Protecting medical advances for the future, while at the same time securing the drug prices Americans want today.” pic.twitter.com/56dvAt1OHi
— HHS.gov (@HHSGov) September 30, 2025
Trump first unveiled his “most-favored-nation” concept in July, pledging to stop what he called “global freeloading” by wealthy countries that had long paid less for the same drugs. He reiterated that his administration is prepared to use tariffs and other leverage to ensure pharmaceutical companies comply.
“This is about fairness for the American people,” Trump said. “For too long, they have carried the burden. That ends today.”